Thakur A, Singh DK, Hart KD, Kis E, Gáborik Z, Denton TT, Clarke JD, Paine MF, Prasad B. From Discovery to Translation: Endogenous Substrates of OAT1 and OAT3 as Clinical Biomarkers for Renal Secretory Function. Clin Pharmacol Ther. 2025 Sep;118(3):693-704. doi: 10.1002/cpt.3719. Epub 2025 May 22. PMID: 40401788; PMCID: PMC12353907.

Ailabouni AS, Singh DK, Thakur A, Boone EC, Gaedigk A, Paine MF, Prasad B. Quantitative Contributions of Hepatic and Renal Organic Cation Transporters to the Clinical Pharmacokinetic Cimetidine-Metformin Interaction. Clin Pharmacol Ther. 2025 Aug;118(2):343-354. doi: 10.1002/cpt.3639. Epub 2025 Mar 17. PMID: 40098288.

Nguyen JT, Arian CM, Tanna RS, Cherel MG, Layton ME, White JR, Thummel KE, Paine MF. The Pharmacokinetic Interaction Between Metformin and the Natural Product Goldenseal Is Metformin Dose-Dependent: A Three-Arm Crossover Study in Adults With Type 2 Diabetes. Clin Transl Sci. 2025 Feb;18(2):e70120. doi: 10.1111/cts.70120. PMID: 39943692; PMCID: PMC11821731.

Qian L, Zhang T, Dinh J, Paine MF, Zhou Z. Physiologically Based Pharmacokinetic Modeling of Cannabidiol, Delta-9-Tetrahydrocannabinol, and Their Metabolites in Healthy Adults After Administration by Multiple Routes. Clin Transl Sci. 2025 Jan;18(1):e70119. doi: 10.1111/cts.70119. PMID: 39748462; PMCID: PMC11695271.

Qian L, Wang Z, Paine MF, Chan ECY, Zhou Z. Application of physiologically-based pharmacokinetic modeling to inform dosing decisions for geriatric patients. CPT Pharmacometrics Syst Pharmacol. 2024 Dec;13(12):2031-2035. doi: 10.1002/psp4.13241. Epub 2024 Sep 18. PMID: 39291626; PMCID: PMC11646931.

Clarke JD, Judson SM, Tian DD, Kirby TO, Tanna RS, Matula-Péntek A, Horváth M, Layton ME, White JR, Cech NB, Thummel KE, McCune JS, Shen DD, Paine MF. Co-consuming green tea with raloxifene decreases raloxifene systemic exposure in healthy adult participants. Clin Transl Sci. 2023 Oct;16(10):1779-1790. doi: 10.1111/cts.13578. Epub 2023 Aug 28. PMID: 37639334; PMCID: PMC10582660.

Nguyen JT, Tian DD, Tanna RS, Arian CM, Calamia JC, Rettie AE, Thummel KE, Paine MF. An Integrative Approach to Elucidate Mechanisms Underlying the Pharmacokinetic Goldenseal-Midazolam Interaction: Application of In Vitro Assays and Physiologically Based Pharmacokinetic Models to Understand Clinical Observations. J Pharmacol Exp Ther. 2023 Dec;387(3):252-264. doi: 10.1124/jpet.123.001681. Epub 2023 Aug 4. PMID: 37541764; PMCID: PMC10658920.

Bansal S, Zamarripa CA, Spindle TR, Weerts EM, Thummel KE, Vandrey R, Paine MF, Unadkat JD. Evaluation of Cytochrome P450-Mediated Cannabinoid-Drug Interactions in Healthy Adult Participants. Clin Pharmacol Ther. 2023 Sep;114(3):693-703. doi: 10.1002/cpt.2973. Epub 2023 Jun 30. PMID: 37313955; PMCID: PMC11059946.

Bansal S, Ladumor MK, Paine MF, Unadkat JD. A physiologically-based pharmacokinetic model for cannabidiol in healthy adults, hepatically-impaired adults, and children. Drug Metab Dispos, online ahead of print, 2023. https://doi.org/10.1124/dmd.122.001128 PMID: 36972999

Tanna RS, Nguyen JT, Hadi DL, Layton ME, White JR, Cech NB, Oberlies NH, Rettie AE, Thummel KE, Paine MF. Clinical assessment of the drug interaction potential of the psychotropic natural product kratom. Clin Pharmacol Ther, online ahead of print, 2023. https://pubmed.ncbi.nlm.nih.gov/36924284. PMID: 36924284

Zamarripa CA, Spindle TR, Surujunarain R, Weerts EM, Bansal S, Unadkat J, Paine MF, Vandrey R. Assessment of orally administered ?9-tetrahydrocannabinol when coadministered with cannabidiol on ?9-tetrahydrocannabinol pharmacokinetics and pharmacodynamics in healthy adults: a randomized clinical trial. JAMA Netw Open, 6(2):e2254752, 2023. https://doi.org/10.1001/jamanetworkopen.2022.54752. PMID: 36780161 PMCID: PMC9926328

Brogdon HD, McPhee MM, Paine MF, Cox EJ, Burns AG. A case of potential pharmacokinetic kratom-drug interactions resulting in toxicity and subsequent treatment of kratom use disorder with Buprenorphine/Naloxone. J Addict Med, online ahead of print, 2022. https://doi.org/10.1097/adm.0000000000000968. PMID: 35165231

Tanna RS, Nguyen JT, Hadi DL, Manwill PK, Flores-Bocanegra L, Layton ME, White JR, Cech NB, Oberlies NH, Rettie AE, Thummel KE, Paine MF. Clinical pharmacokinetic assessment of kratom (Mitragyna Speciosa), a botanical product with opioid-like effects, in healthy adult participants. Pharmaceutics, 14(3):620, 2022. https://doi.org/10.3390/pharmaceutics14030620. PMID: 35335999 PMCID: PMC8950611

Cox EJ, Rettie AE, Unadkat JD, Thummel KE, McCune JS, Paine MF. Adapting regulatory drug-drug interaction guidance to design clinical pharmacokinetic natural product-drug interaction studies: a NaPDI Center recommended approach. Clin Transl Sci, 15(2):322-329, 2021. https://doi.org/10.1111/cts.13172. PMID: 34699676 PMCID: PMC8841492

Cox EJ, Tian DD, Clarke JD, Rettie AR, Unadkat JD, Thummel KE, McCune JS, Paine MF. Modeling pharmacokinetic natural product-drug interactions for decision-making: a NaPDI Center recommended approach. Pharmacol Rev, 73(2):847-859, 2021. https://doi.org/10.1124/pharmrev.120.000106. PMID: 33712517 PMCID: PMC7956993

Zhou Z, Paine MF, Spindle TR, Huang SM, Zhang L. Cannabis for medical use: clinical pharmacology perspectives on scientific and regulatory challenges. Clin Pharmacol Ther, 111(4):732-735, 2021. https://doi.org/10.1002/cpt.2470. PMID: 34784423 PMCID: PMC9022961

Nguyen JT, Tian DD, Tanna RS, Hadi DL, Bansal S, Calamia JC, Arian CM, Shireman LM, Molnár B, Horváth M, Kellogg JJ, Layton ME, White JR, Chech NB, Boyce RD, Unadkat JD, Thummel KE, Paine MF. Assessing transporter-mediated natural product-drug interactions via in vitro-in vivo extrapolation: clinical evaluation with a probe cocktail. Clin Pharmacol Ther, 109(5):1342-1352, 2020. https://doi.org/10.1002/cpt.2107. PMID: 33174626 PMCID: PMC8058163

Tian DD, Leonowens C, Cox EJ, González-Pérez V, Frederick KS, Scarlett YV, Fisher MB, Paine MF. Indinavir increases midazolam glucuronidation in humans: identification of an alternate CYP3A inhibitor using an in vitro to in vivo approach. Drug Metab Dispos 47:724-731, 2019. https://doi.org/10.1124/dmd.119.087007. PMID: 31028057 PMCID: PMC6556520

Tian DD, Natesan S, White JR J, Paine MF. Effects of common CYP1A2 genotypes and other key factors on intraindividual variation in the caffeine metabolic ratio: an exploratory analysis. Clin Translational Sci 12:39-46, 2019. https://dx.doi.org/10.1111%2Fcts.12598. PMID: 30387917 PMCID: PMC63422440

Gufford BT, Ainslie GR, White JR Jr, Layton ME, Padowski JM, Pollack GM, Paine MF. Comparison of a New Intranasal Naloxone Formulation to Intramuscular Naloxone: Results from Hypothesis-generating Small Clinical Studies. Clin Transl Sci. 2017 Sep;10(5):380-386. doi: 10.1111/cts.12473. Epub 2017 May 23. PMID: 28504483; PMCID: PMC5593165.

Gufford BT, Barr JT, González-Pérez V, Layton ME, White JR Jr, Oberlies NH, Paine MF. Quantitative prediction and clinical evaluation of an unexplored herb-drug interaction mechanism in healthy volunteers. CPT Pharmacometrics Syst Pharmacol. 2015 Dec;4(12):701-10. doi: 10.1002/psp4.12047. Epub 2015 Nov 28. PMID: 26904384; PMCID: PMC4759704.